On an account-model chain, every transaction from an address carries a sequential nonce. The network executes them strictly in order, which prevents replay and guarantees deterministic sequencing.
This is why a stuck transaction blocks the ones behind it, and why "cancelling" means replacing the same nonce with a different transaction at a higher fee rather than deleting anything.
In proof-of-work, nonce means something else: the field miners increment while hashing a block candidate, billions of times per second, hunting for an output under the difficulty target. Same word, unrelated job.
Related: account-model, replace-by-fee, mempool, proof-of-work