Signals are typically weak, with information ratios per position that look negligible. The strategy works by breadth: hundreds or thousands of positions, held for days, with the book constructed neutral to market, sector and factor exposures.
Turnover is high and capacity is limited, so results depend on transaction cost modelling as much as on signal research. A signal that is profitable on paper frequently disappears once realistic slippage is applied.
The standing risk is that many participants have found the same signals. The August 2007 unwind, when crowded quant books fell sharply together and largely recovered within days, showed that neutrality to factors does not protect against neutrality to other people's leverage. See factor-crowding and pairs-trading.
Related: pairs-trading, factor-crowding, market-neutral, slippage, backtesting, mean-reversion